Table II.

Virus-specific CD8 T cell responses in healthy elderly donorsa

AgHLA RestrictionPeptideResponders/Donors TestedMean FrequencyRange of Frequencies
CMVA2VLE14/261.250–22.3
IE-1B7CRVb17/182.20–8.7
B8QIK7/1320–13.8
ELK/R8/137.850–32.1
CMVA1VTE19/193.40.2–32.4
pp50
CMVA1YSE8/190.240–1.6
pp65A2NLV26/263.50.1–18.2
B7TPR17/183.60–10.7
RPH16/181.20–6.2
B35IPS3/41.250–4.2
EBV lyticA2GLC36/400.940–10.4
YVL23/400.240–2.8
B8RAK16/201.350–12.2
B35EPL5/80.670–1.8
EBV latentA2CLG21/400.10–0.5
B8FLR13/200.350–2.7
QAK9/200.20–1.4
B35HPV5/80.280–0.65
YPL5/80.30–0.75
Flu MPA2GIL19/400.0250–0.2
Flu NPB8ELRS5/200.020–0.16
  • a Values indicate tetramer binding frequencies of CD8 T cells.

  • b Frequencies for the CRV-specific CD8 T cells were derived by detection of peptide-induced IFN-γ (B7-CRV monomers could not be refolded).