Table I.

BAFF/APRIL blockade in bcl-2 Tg mice

TreatmentB Cellsa (×107)CD21/35b (MFI)CD23b (MFI)
BCMA-Fc15.813.7145
BCMA-Fc16.013.0136
BCMA-Fc24.312.1174
Mean ± SD18.7 ± 4.912.9 ± 0.8151.7 ± 19.9
 hIgG21.816.9256
 hIgG20.719.2279
 Mean21.318.1268
  • a Assessed on day 8 after 2 doses of BCMA-Fc.

  • b Assessed 2 days after a single dose of BCMA-Fc.