Table I.

lpg2 parasites induce comparable early inflammatory and proliferative responses as WT L. majora

Cells/LN ± SE (×106)Proliferation ± SE (×103 cpm)
MediumSLAAnti-CD3
Uninfected1.9 ± 0.20.2 ± 0.50.3 ± 0.157.1 ± 12.6
WT14.6 ± 0.58.5 ± 1.516.7 ± 1.939.7 ± 1.2
lpg2 17.0 ± 3.825.6 ± 3.721.3 ± 3.750.2 ± 1.30
lpg2−/+ LPG214.0 ± 4.025.8 ± 10.828.4 ± 4.765.3 ± 18.3
  • a Naive (uninfected) mice or BALB/c mice infected for 3 days with WT, lpg2, or lpg2/LPG2 L. major were sacrificed and the total number of cells in the draining popliteal LNs were enumerated. Cells were stimulated with SLA or anti-CD3/anti-CD28 for 3 days and pulsed with [3H]thymidine for 18 h, and cellular proliferation was measured by counting the amount of radioactivity incorporated by the cells.