Table I.

Immune cell populations of IL-23p19−/− micea

Wild TypeKnockoutp (Diff.)
Thymus
 CD4+5.7 ± 0.55.5 ± 0.00.504
 CD8+3.3 ± 0.13.1 ± 0.30.397
 DN25.0 ± 4.217.0 ± 8.00.202
 DP65.9 ± 3.774.3 ± 8.00.174
Spleen
 CD4+24.3 ± 0.822.5 ± 2.70.342
 % Naive69.0 ± 1.367.5 ± 2.10.090
 % Memory29.1 ± 1.231.0 ± 1.90.029
 CD8+15.2 ± 1.212.3 ± 2.00.101
 % Naive64.1 ± 5.467.0 ± 2.80.199
 % Memory18.1 ± 1.818.3 ± 1.40.084
 I-A(b)+/CD11c+2.0 ± 0.22.2 ± 0.20.041
 %CD8+12.8 ± 0.916.3 ± 1.70.000
 %CD887.2 ± 0.983.6 ± 1.80.000
 CD19+52.4 ± 2.055.2 ± 6.50.512
 B220+52.0 ± 2.055.5 ± 5.30.360
 NK1.1+3.2 ± 0.12.8 ± 0.10.055
Peripheral blood
 CD3+47.9 ± 2.644.9 ± 3.60.053
 CD4+28.2 ± 2.326.9 ± 2.50.270
 CD8+16.5 ± 0.815.6 ± 1.70.150
 CD19+43.2 ± 3.245.2 ± 3.60.215
 B220+44.9 ± 3.546.4 ± 4.80.466
 DX5+9.9 ± 3.09.7 ± 5.00.929
 CD16+8.0 ± 0.98.6 ± 1.50.302
 I-A(b)+44.0 ± 1.945.4 ± 4.90.428
  • a Thymocytes, splenocytes, and peripheral blood leukocytes were harvested from three male and three female mice of either genotype. Average percentages and SD of cells staining positive for each marker are shown. A Student’s t-test was used to calculate the probability (p) values of whether differences between the genotypes are statistically significant. DN, double negative; DP, double positive.