Table I. Notch1 mutations in pLCK-DKO mice with T-ALL
T-ALLNT1NT2PEST MutationPEST Amino Acid
1YNc.7193_7194insAGAATAATApSer2397fsX3
2YNc.7194_7195insAGGGp.Ala2399ArgfsX11
3YNc.7080_7081insGGp.Leu2362GlyfsX128
c.7115_7118delCAGG
4YNNDND
5YYc.7051_7052insAAp.Pro2351fsX39
6YNDNDND
7YNDc.7081_7082delG,insACCp.Arg2361HisfsX35
8YNNDND
9YNNDND
10YNNDND
11YNc.7081_7082insAGGGGCCCp.Arg2361GlnfsX129
12YYc.7193_7194insCCp.Ser2397fsX12
13YNNDND
14YNDNDND
15YNc.7081_7082delG,insCCCp.Arg2361ProfsX36
16YNNN/A
17YNc.7193_7194insAGGGp.Ala2399ArgfsX92
18YNc.7081_7082insCCp.Arg2361ProfsX36
19YNNDND
  • N, no; N/A, not applicable; Y, yes.