Increased deposits of IgA, but not of IgG, in the glomeruli of (NZW × B6) F1-hbcl-2 Tg micea
| Mice | IgM | IgG | IgA |
|---|---|---|---|
| B6 non-Tg | − | − | − |
| B6-hbcl-2 Tg | − | − | − |
| NZW | ++ | − | − |
| (NZB × NZW)F1 | +++ | +++ | ND |
| (NZW × B6)F1 non-Tg | ++ | − | − |
| (NZW × B6)F1-hbcl-2 Tg | +++ | − | +++ |
a The presence of glomerular IgM, IgG, and IgA deposits in the different strain of mice (n = 3 mice/group) was evaluated by immunofluorescence on kidney cryosections at 6 mo of age. The intensity of fluorescence is indicated (0 to +++). ND, not done.