Table II.

Summary of biochemical and functional parameters of mH Ag presentation and recognition

mH AgDensitya per CellClass I-Binding ParametersSurface t1/2 (hours)Functional Avidity
Kd2b (nM)t1/2c (hours)SyntheticdNaturaleCytotoxicityf (nM)ICSg (nM)
H60∼30–900.8 ± 0.054.8 ± 0.1>6.0∼6.0–120.9–5.0 × 10−54.0 × 10−4
H28Low82.0 ± 2.91.1 ± 0.04∼2.0∼3.01.0–2.0 × 10−12.4 × 100
H4b∼30–800.8 ± 0.041.8 ± 0.1>6.0∼7.5–120.1–2.0 × 10−43.9 × 10−4
H13b∼39038.0 ± 1.31.1 ± 0.37∼6.0∼3.0–5.01.0–3.5 × 10−16.0 × 101
H7bLow7.0 ± 2.41.6 ± 0.18NDND∼2.5 × 10−45.5 × 100
H3abLow7.0 ± 1.81.7 ± 0.65NDND∼1.0 × 10−15.5 × 101
HYLow250.0 ± 4.61.3 ± 0.09∼2.0∼3.0>1.0 × 1025.3 × 10−1
  • a Density indicates the number of epitopes generated per cell; it does not mean the number of Ags presented on the cell surface; based on Fig. 2 and data not shown (n = 2).

  • b See Fig. 3A (n = 3).

  • c See Fig. 3B (n = 3).

  • d Based on the t1/2 of 1.0 nM peptide-pulsed targets shown in Fig. 4A.

  • e See Fig. 4B (n = 2).

  • f See Figs. 5A, and data not shown (n = 2).

  • g See Fig. 5B (n = 3).