Table I.

Clone T1D1 response

Cell TypesCell LinesHLA-A11IFN-γ (pg/ml)
 None0a
Melanomas
697+b0
836+b0
1011+b581
1913+b1564
1770+b0
1228+b0
1278+b0
1833+b0
1851+b0
1927+b0
2048+b0
6240
8880
5260
19090
1909+c0
1087+c0
B lymphocytes
 EBVBs697+0
836+0
1743+0
 B-CD40L1913+0
Renal carcinoma cells (RCC)
2206R+c0
UOK130+c0
2192R+c0
1743+c0
2193R+c0
  • a T1D1 T cells (104) were incubated with the indicated target cells (2.5 × 104) for 18 h followed by the measurement of IFN-γ release.

  • b Cell lines derived from HLA-A11+ patients tested by genome typing.

  • c Cell lines were transduced with retroviral vector-expressed HLA-A11 Mut, which was isolated from 1913 mel.