Table I.

Expression of B7-H4 in human cancer tissues

DiagnosisSpecimen Numbers, Positive/Total (%)Cases with Staining Intensitya
Lung cancer5/16 (31)11113
 Squamous cell carcinoma4/62013
 Large cell carcinoma1/21100
 Neuroendocrine carcinoma0/11000
Ovarian cancer
 Adenocarcinoma22/26 (85)41417
Melanoma0/17 (0)17000
  • a Intensity of staining by mAb against B7-H4: −, negative; +, focal expression in 10–40% of cancer tissues; ++, focal expression in 40–80% of cancer tissues; +++, diffuse expression in >80% of cancer tissues.