Table II.

Thymocyte subpopulations in 2C/RAG2−/− and 2C/RAG2−/−/PD-1−/− micea

GenotypeNumber of MiceMean Age (wk)Thymus
Cell numberDN (%)DP (%)SP CD8+ (%)Calculated total number DNCalculated total number DPCalculated total number SP CD8+
+/+77.00103.7 ± 42.38.1 ± 4.066.8 ± 8.118.7 ± 9.58.0 ± 3.670.8 ± 35.418.9 ± 11.6
−/−76.7132.1 ± 15.235.9 ± 13.731.9 ± 15.723.6 ± 7.611.1 ± 7.010.9 ± 9.87.0 ± 2.5
p = 0.004p = 0.001p = 0.001p = 0.310p = 0.330p = 0.005p = 0.038
  • a All numbers are shown as mean ± SD. DN, CD4/CD8 DN thymocytes; DP, CD4/CD8 DP thymocytes; SP, CD8 SP thymocytes.