Table I.

Effect of Ag-specific tolerization on myocarditis in T. cruzi-infected micea

DiseaseTolerogenScoresTotal
01234
InflammationT. cruziNone0 (0%)2 (5%)25 (68%)10 (27%)0 (0%)37
BSA0 (0%)0 (0%)19 (59%)13 (41%)0 (0%)32
Myosin0 (0%)0 (0%)24 (75%)8 (25%)0 (0%)32
T. cruzib0 (0%)7 (21%)26 (76%)1 (3%)0 (0%)34
Myosin/CFABSA4 (25%)9 (56%)3 (19%)0 (0%)0 (0%)16
Myosinc14 (70%)6 (30%)0 (0%)0 (0%)0 (0%)20
NecrosisT. cruziNone5 (14%)18 (49%)10 (27%)4 (11%)0 (0%)37
BSA0 (0%)23 (72%)7 (22%)2 (6%)0 (0%)32
Myosin1 (3%)21 (66%)10 (31%)0 (0%)0 (0%)32
T. cruzi1 (3%)19 (56%)14 (41%)0 (0%)0 (0%)34
Myosin/CFABSA3 (19%)12 (75%)1 (6%)0 (0%)0 (0%)16
Myosin10 (50%)10 (50%)0 (0%)0 (0%)0 (0%)20
ParasitosisT. cruziNone4 (11%)16 (43%)17 (46%)0 (0%)0 (0%)37
BSA3 (9%)15 (47%)13 (41%)1 (3%)0 (0%)32
Myosin6 (19%)15 (47%)11 (34%)0 (0%)0 (0%)32
T. cruzib0 (0%)8 (24%)25 (74%)1 (3%)0 (0%)34
Myosin/CFABSA16 (100%)0 (0%)0 (0%)0 (0%)0 (0%)16
Myosin20 (100%)0 (0%)0 (0%)0 (0%)0 (0%)20
FibrosisT. cruziNone0 (0%)16 (43%)8 (22%)11 (30%)2 (5%)37
BSA0 (0%)16 (50%)11 (34%)5 (16%)0 (0%)32
Myosin1 (3%)15 (47%)13 (41%)2 (6%)1 (3%)32
T. cruzi0 (0%)13 (38%)15 (44%)6 (18%)0 (0%)34
Myosin/CFABSA4 (25%)10 (63%)2 (13%)0 (0%)0 (0%)16
Myosind16 (80%)4 (20%)0 (0%)0 (0%)0 (0%)20
  • a The number of mice and percentage in the group receiving a particular score are given. Saline-injected mice (n = 10) and saline/CFA-immunized mice (n = 10) received scores of 0 for all parameters.

  • b , p < 0.05 compared with BSA-tolerized and untolerized mice.

  • c , p < 0.05 compared with BSA-tolerized mice.

  • d , p < 0.005 compared with BSA-tolerized mice.