Table I.

Genotypic characterization of the IL-12b allele and Idd4 intervals in recombinant congenic murine strains

StrainaIL-12p40 AllelebIL-12p40 Expression DefectIdd4 Locusc
506 nt880 ntInterval (cM)Markers
C57BL/6TTNoneNone
B6.NOD.Idd1TTNoneNone
B6.NOD.Idd1/3/10TTNoneNone
B6.NOD.Idd4CC+20–72D11Mit20
D11mit42
B6.NOD.Idd1/Idd4CC+20–72D11Mit20
D11mit42
B6.NOD.Idd1/Idd5TTNoneNone
B6.NOD.Idd1/Idd6TTNoneNone
B6.NOD.Idd13TTNoneNone
CBATTNoneNone
CBc.NO7CTT40–48D11Acrb
D11Mit36
CBc.NO6TT40–70D11Acrb
D11Mit214
NOcCB-1CC+17–40D11Mit84
D11Acrb
NODCC+n.a.n.a.
DBA/2CdCddn.a.n.a.
  • a Recombinant congenic strains with Idd4 loci on a C57BL/6 background (13 ) or with roughly 50% CBA and 50% NOD genomes with different combinations of Idd loci (12 ).

  • b Polymorphism in the IL-12p40 allele that distinguishes the NOD from the C57BL/6 and CBA alleles (14 ).

  • c Idd4 intervals on murine chromosome 11 defined by different microsatellite markers (12 ,13 ).

  • d Refs. 6 and 14 .