Table I.

Surveyed innate immunity genes in GeneChip microarray

ClassificationU-95 Av2Gene Accession No.Mean AD ± SEaMean PS ± SEat Testb
Cytokines and chemokines
TNF-α1852_atX02910156 ± 32162 ± 14
IL-1β39402_atM15330195 ± 28692 ± 229
IL-638299_atX0443038 ± 1445 ± 11
IL-12563_atM6529018 ± 616 ± 3c
IFN-γ40702_atX1327432 ± 1154 ± 15
IL-835372_r_atM1701763 ± 12600 ± 210p = 0.044
IL-8Rβ664_atL1959362 ± 9122 ± 12p = 0.0023
IL-41574_s_atM1398272 ± 1768 ± 14
IL-13494_atU31120135 ± 3584 ± 20
Toll-like receptors
TLR136243_atAL05026297 ± 2181 ± 17
TLR240310_atAF051152108 ± 10161 ± 26
TLR333488_atU8887952 ± 1625 ± 5
TLR534473_atAF05115162 ± 1269 ± 15
TLR634144_atAB02080786 ± 1879 ± 16
Phagocytosis-promoting receptors
MARCOd40331_atAF035819126 ± 4194 ± 41
β1 integrins32808_atX079792489 ± 1322305 ± 228
E-cadherin2082_s_atL08599378 ± 69379 ± 32
CD3636656_atM9839949 ± 774 ± 11
CD11b38533_s_atJ0392552 ± 2635 ± 11
CD3535892_atY0081638 ± 734 ± 10
Mannose receptor36908_atM93221312 ± 74217 ± 38
CD1436661_s_atX06882108 ± 10161 ± 26
Complement
C1r39409_atM140582869 ± 3262467 ± 109
C1q B chain38796_atX03084620 ± 141815 ± 249
C1r40496_atJ040802485 ± 4642310 ± 408
C440766_atU24578253 ± 44200 ± 48
C537816_atM5772944 ± 932 ± 10
Anti-microbial peptides, enzymes
(from neutrophils)
Defensin, α131793_atAL03655461 ± 1273 ± 24
Defensin, α434546_atAI25079966 ± 949 ± 14
Defensin, α634622_atU3331719 ± 918 ± 3
Defensin, α534623_atM9792549 ± 2351 ± 14
Azurocidin33963_atM9632655 ± 934 ± 3
Cathepsin C133_atX872122875 ± 4762063 ± 287
Cathepsin D239_atM631384496 ± 2876488 ± 444p = 0.0037
Cathepsin H37021_atX168321630 ± 1482604 ± 312p = 0.021
(from keratinocytes)
iNOS1948_f_atU3151165 ± 9299 ± 71p = 0.016
HBD-139660_atAI3091153255 ± 1484279 ± 348p = 0.027
HBD-232464_atAF07121613312 ± 426445863 ± 4177p = 0.00021
Signal transduction
MyD88d38369_atU704511063 ± 1201235 ± 118
TRAF6d1209_atU7879872 ± 1181 ± 12
NF-κB11377_atM58603743 ± 70808 ± 61
NF-κB240363_r_atU0960978 ± 1064 ± 8
  • a Mean signal intensity ± SE of six AD skin biopsies and seven psoriasis (PS) skin biopsies.

  • b Two-tailed unpaired t test comparing AD vs psoriasis.

  • c Signal intensity under 100 is considered as under the detection limit by software used.

  • d MARCO, macrophage scavenger receptor with collagenous structure; MyD88, myeloid differentiation factor 88; TRAF, TNFR-associated factor.