Table I.

Surveyed innate immunity genes in GeneChip microarray

Classification	U-95 Av2	Gene Accession No.	Mean AD ± SE^a	Mean PS ± SE^a	t Test^b
Cytokines and chemokines
TNF-α	1852_at	X02910	156 ± 32	162 ± 14
IL-1β	39402_at	M15330	195 ± 28	692 ± 229
IL-6	38299_at	X04430	38 ± 14	45 ± 11
IL-12	563_at	M65290	18 ± 6	16 ± 3^c
IFN-γ	40702_at	X13274	32 ± 11	54 ± 15
IL-8	35372_r_at	M17017	63 ± 12	600 ± 210	p = 0.044
IL-8Rβ	664_at	L19593	62 ± 9	122 ± 12	p = 0.0023
IL-4	1574_s_at	M13982	72 ± 17	68 ± 14
IL-13	494_at	U31120	135 ± 35	84 ± 20

Toll-like receptors
TLR1	36243_at	AL050262	97 ± 21	81 ± 17
TLR2	40310_at	AF051152	108 ± 10	161 ± 26
TLR3	33488_at	U88879	52 ± 16	25 ± 5
TLR5	34473_at	AF051151	62 ± 12	69 ± 15
TLR6	34144_at	AB020807	86 ± 18	79 ± 16

Phagocytosis-promoting receptors
MARCO^d	40331_at	AF035819	126 ± 41	94 ± 41
β₁ integrins	32808_at	X07979	2489 ± 132	2305 ± 228
E-cadherin	2082_s_at	L08599	378 ± 69	379 ± 32
CD36	36656_at	M98399	49 ± 7	74 ± 11
CD11b	38533_s_at	J03925	52 ± 26	35 ± 11
CD35	35892_at	Y00816	38 ± 7	34 ± 10
Mannose receptor	36908_at	M93221	312 ± 74	217 ± 38
CD14	36661_s_at	X06882	108 ± 10	161 ± 26

Complement
C1r	39409_at	M14058	2869 ± 326	2467 ± 109
C1q B chain	38796_at	X03084	620 ± 141	815 ± 249
C1r	40496_at	J04080	2485 ± 464	2310 ± 408
C4	40766_at	U24578	253 ± 44	200 ± 48
C5	37816_at	M57729	44 ± 9	32 ± 10

Anti-microbial peptides, enzymes
	(from neutrophils)
Defensin, α1	31793_at	AL036554	61 ± 12	73 ± 24
Defensin, α4	34546_at	AI250799	66 ± 9	49 ± 14
Defensin, α6	34622_at	U33317	19 ± 9	18 ± 3
Defensin, α5	34623_at	M97925	49 ± 23	51 ± 14
Azurocidin	33963_at	M96326	55 ± 9	34 ± 3
Cathepsin C	133_at	X87212	2875 ± 476	2063 ± 287
Cathepsin D	239_at	M63138	4496 ± 287	6488 ± 444	p = 0.0037
Cathepsin H	37021_at	X16832	1630 ± 148	2604 ± 312	p = 0.021
	(from keratinocytes)
iNOS	1948_f_at	U31511	65 ± 9	299 ± 71	p = 0.016
HBD-1	39660_at	AI309115	3255 ± 148	4279 ± 348	p = 0.027
HBD-2	32464_at	AF071216	13312 ± 4264	45863 ± 4177	p = 0.00021

Signal transduction
MyD88^d	38369_at	U70451	1063 ± 120	1235 ± 118
TRAF6^d	1209_at	U78798	72 ± 11	81 ± 12
NF-κB1	1377_at	M58603	743 ± 70	808 ± 61
NF-κB2	40363_r_at	U09609	78 ± 10	64 ± 8

a Mean signal intensity ± SE of six AD skin biopsies and seven psoriasis (PS) skin biopsies.
b Two-tailed unpaired t test comparing AD vs psoriasis.
c Signal intensity under 100 is considered as under the detection limit by software used.
d MARCO, macrophage scavenger receptor with collagenous structure; MyD88, myeloid differentiation factor 88; TRAF, TNFR-associated factor.