Table III.

Relationship between changes of motif and motif surrounding amino acidsa

HLA (Serological Designation)HC-10-Reactive Alleles (p-Defined Group No.; Motif-Aa Substitutions)HC-10-Nonreactive Alleles (p-Defined Group No.; Motif-Aa Substitutions)Alleles with Motif-Surrounding Aa Substitutions (Alleles; Aa; p-Defined Group no.)
p-1a; R62(N63)p-1b; R62(E63)p-2; E62p-3; Q62p-4; G62p-5; L62p-6; S57p-7; E61–E62
A1A0101bA*0107; R56; p-3
2A*0246,48A*0245A*0201bA*0228; S56; p-4
3A*0301b
11A*1110A*1101b
23A*2301b
24A*2424A*2402bA*2408A*2431;Q63; p-2
25A*2501c
26A*2601cA*2607
29A*2902b
30A*3007A*3003,11A*3001b; R56; p-3
31A*3101A*31; R56; p-3
32A*3201bA*3205; G65; p-3
33A*3303cA*3305; R54; p-1a
34A*3401cA*3404; R56; p-1a
36A36
43A43
66A66
68A*6802A*6813A*6810,14
69A*6901c
74A*7401bA*7404
80A*8001A*8001;E56; p-2
Bd08B0801cB*0810; D63; p-1a
15B*1501cB*1528; 164; p-1b
27B*2723B*2705cB*2703; H59; p-1b
B*2717; F59; p-1b
38B*3801B*3803,04B*3807;G58; p-1a
55B55B*5505; A59; p-1a
57B*5702b
58B*5804B58
CWAllCW*0702cCW*0607; K54; p-1b
EAllEb
GAllGb
  • a Relationship between changes of motif and motif surrounding amino acids (Aa) of the mAb HC-10-defined peptide (p) E55-T64 from classical and nonclassical HLA class I allele products and their reactivity with mAb HC-10.

  • b Assessed by one-dimensional gel isoelectric focusing or immunofluorescence assay to be not-reactive with mAb HC-10.

  • c Assessed by one-dimensional gel isoelectric focusing to be reactive with mAb HC-10.

  • d Only alleles falling in groups other than p-1a/b and those with motif-surrounding Aa substitutions are indicated.

  • Bold text indicates that all remaining alleles with the given serological designation fall in this group.