Table II.

Role of CD28-B7 costimulatory pathway in abscess formation

GroupNo. of Animals with Abscess/Total (%)ap Value
Wild type+/+9/10 (90)
CD28−/−2/10 (20)0.006b
CTLA4Igc3/10 (30)0.02d
L6Igc9/10 (90)NSd
Saline9/10 (90)
  • a Challenged via the i.p. route with 1 × 108 CFU of B. fragilis and SCC.

  • b Compared with wild-type control.

  • c The fusion protein (500 μg/ml) was administered to mice via the intracardiac route.

  • d Compared with sham-depleted control.