Table I.

T cell phenotype responsible for intra-abdominal abscess formation in animals

GroupNo. of Animals with Abscess/Total (%)ap Value
αβTCR+ T cell depleted2/8 (25)0.01b
CD4+ T cell depleted2/10 (20)0.02b
CD8+ T cell depleted8/10 (80)NS
Sham depleted9/10 (90)
Wild type+/+15/18 (83)
αβTCR−/−3/10 (30)0.01c
CD4−/−4/20 (20)0.0002c
CD8−/−15/20 (75)NS
  • a Challenged via the i.p. route with 1 × 108 CFU of B. fragilis and SCC.

  • b Compared with sham-depleted control.

  • c Compared with wild-type littermate control.