Table VI.

HIV-1 p24 peptide-specific, IFN-γ-producing CD4+ T cell responses detected using expanded PBMC from HIV-1-infected subjects with immune reconstitution

CD4 Nadira CD4 at StudyUH64UH116UH117UH118UH119UH120
9 98324 87732 625180 545108 70331 382
HIV-1 p24 Peptide-Specific Responses (net mean SFCs/106 expanded cells)b
131–150c108
141–160
151–170227
161–18092108
171–190
181–200311267
191–210108
201–220
211–230522
221–240
231–250108
241–260513
251–270
261–280100422721
271–290400370
281–300
291–310789156120721
301–320367
311–330213
321–340
331–350529
341–360193147
351–370167144
361–375
371–390
No. of peptides targeted563534
  • a Peripheral blood CD4 counts, expressed as cells per microliter.

  • b The magnitude of each peptide-specific response was calculated according to the following formula: (mean SFCs per peptide well − mean SFCs per control well)/(cells plated/well/106). A peptide-specific response was considered significant if the mean SFCs per peptide well was at least 3 SFCs greater than the mean SFCs per negative control well and more than 2 SD greater than the mean SFCs per negative control well. Peptide-specific responses that did not meet these criteria are shown as dashes.

  • c HIV-1 p24-derived peptides designated by residue positions within the complete HXB2 Gag amino acid sequence.