Table V.

Sequence conservancy of CD4+ T cell clone target epitopes among reported HIV sequences

CloneRecognition SequenceConservancy Within Clade BaConservancy Among All Isolatesb
6KIVRMYSPT24 /37 (65)25 /162 (15)
3B4PKEPFRDYV34 /37 (92)152 /162 (94)
3G7/4E10EWDRVHPVHA4 /37 (11)32 /162 (20)
4F5EVIPMFSALS34 /37 (92)112 /162 (69)
5D8EEKAFSPEV37 /37 (100)123 /162 (76)
6C10PIVQNIQGQ10 /37 (27)12 /162 (7)
8F10EQIGWMTN25 /37 (68)32 /162 (20)
  • a The epitope recognition sequence determined for each clone as in Fig. 2 was aligned with all HIV-1 clade B sequences at the same residue positions in the Los Alamos National Laboratories HIV sequence database using the Epilign program. The numbers and percentages (in parentheses) of reported isolates with identical amino acid sequences at the given positions are shown.

  • b The same alignment procedure was carried out using all reported HIV sequences.