Table IV.

Functional avidities of p24-specific CD4+ T cell clones

CloneTarget Peptide SequenceMEDa p24MED Peptideb
6LNKIVRMYSPTSI4.17 × 10−74.17× 10−7
3G7AAEWDRVHPVHAG4.17× 10−7>4.17× 10−6
4E10AAEWDRVHPVHAG4.17× 10−8>4.17× 10−6
4F5PEVIPMFSALSEG4.17× 10−74.17 × 10−6
6C10PIVQNIQGQMVHQ4.17× 10−84.17× 10−6
8F10TSTLQEQIGWMTN4.17× 10−94.17 × 10−7
  • a MED, Minimal effective dose, defined as the lowest tested Ag concentration that stimulated proliferation at least 3 SD above and 2 times as great as background.

  • b For each clone, the 13-aa p24 peptide that stimulated the strongest response in mapping studies was used (see Fig. 2 for example of mapping results).