Table V.

Levels of OH-proline, fibronectin, and collagen type I after repeated T.O. administration of mouse rIL-12p40 in silica-treated C57BL/6 or IL-12p40−/− mice (2 mo, 2.5 mg silica)

C57BL/6 + PBSC57BL/6 + rIL-12p40IL-12p40−/− + PBSIL-12p40−/− + rIL-12p40
OH-proline (μg/lung)214.7 ± 15.0251.4 ± 3.9176.2 ± 23.8233.1 ± 10.4a
Collagen I (mg/lung)10.7 ± 0.712.6 ± 0.69.6 ± 0.212.5 ± 0.5a
Fibronectin (μg/lung)79.1 ± 5.887.6 ± 2.559.4 ± 8.985.0 ± 7.3a
  • a , p < 0.05; denotes significant differences in values measured in rIL-12p40-administrated mice compared with corresponding PBS-administrated mice.