Table IV.

In vitro IFN-γ and IL-4 production of lung T cells purified from saline or silica-treated C57BL/6, IL-12p35−/−, and IL-12p40−/− mice (2 mo, 2.5 mg silica)

IFN-γIL-4
C57BL/6IL-12p35−/−IL-12p40−/−C57BL/6IL-12p35−/−IL-12p40−/−
T cells
without Con ASalineN.D.aN.D.N.D.N.D.N.D.N.D.
Silica37.4 ± 11.739.0 ± 12.510.3 ± 5.0bN.D.N.D.N.D.
with Con ASaline280.4 ± 63.3434.0 ± 24.6440.3 ± 28.0137.2 ± 11.0164.1 ± 6.9131.9 ± 12.2
Silica847.8 ± 12.5757.3 ± 10.5c789.0 ± 19.8b52.0 ± 8.720.6 ± 2.7d17.1 ± 3.4d
  • a N.D., Not detected.

  • b , p < 0.05;

  • c , p < 0.01;

  • d , p < 0.001; denote significant differences in values measured in silica-treated IL-12p35−/− and IL-12p40−/− mice compared with silica-treated C57BL/6 mice.