Table I. XBP1 DC-targeting DNA vaccine reduces tumor spontaneous bone marrow metastases
DNA VaccinesMice with Bone Marrow Metastases/Mice Used in Experiments
XBP110/15
NeuEDhsp708/15
XBP1/NeuEDhsp701/15
Untreated6/10
  • Tumor-bearing BALB/c mice were untreated or vaccinated by DNA (Fig. 2A). On day 30, tumor cells in bone marrow were selected, and data from two independent experiments are shown and were statistically analyzed (26). XBP1/NeuEDhsp70 versus untreated, NeuEDhsp70, or XBP1: p < 0.05.