HL-60 genes differentially expressed during A. phagocytophila infection as identified by cDNA microarray screening
| Gene | Encoded Protein | Biological Role(s) | Differential Expression Scorea |
|---|---|---|---|
| bpi | Bactericidal membrane permeability-increasing protein | Anti-Gram− peptide; induces growth arrest and outer membrane permeation, neutralizes endotoxin, opsonic factor (31 ) | 1 |
| c-myc | c-Myc | Transcription factor; apoptosis, cell growth, metabolism (32 ) | 2 |
| mpo | Myeloperoxidase | Microbicidal; converts H2O2 to HOCl (34 ) | 2.5 |
| mbn | Myeloblastin | Regulates proliferation and differentiation of HL-60 cells (33 ) | 2 |
| rac2 | Rac2 | NADPH oxidase activation (9 10 ) | 1 |
| fth | Ferritin heavy chain | Intracellular iron storage (35 ) | 5 |
| IL-8 | IL-8 | Neutrophil chemokine; attracts PMNs to site of infection (36 ) | 4 |
| IL-1β | IL-1β | Proinflammatory cytokine (37 ) | 3.5 |
a Differential expression score ranges from 1 (strongly down-regulated during A. phagocytophila infection) to 5 (strongly up-regulated during infection); a score of 3 represents equivalent expression between uninfected and infected cells.