Table II.

Inhibition of sporozoite invasion of HepG2 cells by anti-repeat mAb

mAb 2A10 (μg/ml)mAb 3D11 (μg/ml)No mAb
25a2.50.25252.50.25
CS(Pf)99b (2, 5)88 (93, 74)53 (324, 331)0 (670, 756)0 (786, 803)0 (777, 823)(723, 686)
CS(sx)<1 (501, 431)0 (519, 462)0 (494, 470)100 (0, 0)97 (15, 10)46 (263, 244)(431, 507)
wt4 (660, 657)0 (685, 701)0 (695, 693)100 (0, 0)98 (11, 9)51 (275, 302)(663, 715)
  • a Concentration of mAb added to HepG2 cells 1 h prior to addition of sporozoites.

  • b Percentage of inhibition. Total number of EEF per duplicate coverslip in parentheses.