Table 3.

CAMHC peptides induce EAMC and DCM in SWXJ mice

PeptideType of EAMC InductionIncidence of EAMCMean % of Heart Showing InflammationaHeart Wt: Body Wt RatiobIncidence of DCMc
pα406–425Active6 /83.38 ± 1.755.1 ± 0.25 /8
Passive6 /84.88 ± 2.295.3 ± 0.25 /8
pα1631–1650Active4 /83.21 ± 1.125.0 ± 0.23 /8
Passive4 /73.52 ± 1.205.3 ± 0.33 /7
PBS controlNone0 /404.0 ± 0.60 /4
  • a The percentage of heart tissue involved in inflammation was determined in a blinded manner, as described in Materials and Methods.

  • b Heart weight:body weight ratios were determined by dividing heart weight (mg) by body weight (g).

  • c DCM was determined by the presence of fibrotic tissue, an increase in the radius of one or both ventricular chambers without a proportionate increase in mural wall thickness, and an increase in the heart weight:body weight ratio.