Table 4.

Normal mouse LP CD4+ T cells have Tr1-like activitya

T CellAPC+bLPLcOthercpm ± SD
Th1646 ± 42
Th1CBA49,832 ± 9,684
Th1CBA+11,970 ± 5,035
Th1CBA+Anti-IL-1032,611 ± 10,721
Th1CBA+Anti-IL-413,467 ± 3,033
Th1Anti-CD330,082 ± 2,269
Th1+Anti-CD328,564 ± 3,938
  • a Th1 cells were cultured with or without LP CD4+ T cells in the presence or absence of various Ab. [3H]TdR (0.5 μCi) was added to the wells for the last 18 h of a 5-day culture. Results are expressed as mean cpm ± SD of triplicate cultures and are representative of three experiments with similar results.

  • b +, APC pulsed with CBA or medium alone as shown.

  • c LPL, LP CD4+ T cells.