Table I.

Survival of C57BL/6 heart allografts and chimerism in BALB/c hosts given ATS, TLI, and/or donor bone marrow cells

Host TreatmentHeart Allograft Survival (days)Median Survival (days) (± SD)Percentage of Donor Type Cells Amongst White Blood Cells of Hostd
ATSaTLIbBone marrow cellsc
9, 14, 14, 14, 17, 1714 (±3)NA
+25, 27, 27, 29, 33, 3428 (±4)NA
+13, 14, 17, 20, 45, 48, 5520 (±18)NA
++38, 45, 48, 49, 50, 52, 55, 5949 (±6)NA
++20, 20, 20, 21, 21, 22, 2321 (±1)<1, <1, <1, <1, <1, <1, <1
++21, 23, 27, 27, 27, 35, 59, >10027 (±27)68, 74, 80, 88, 97, >99, >99
+++35, 77, >100, >100, >100, >100, >100, >100, >100, >100, >100, >100, >100>100 (±20)51, 54, 56, 57, 58, 58, 58, 60, 60, 61, 64, 65
  • a Five doses of 50 μl, i.p. given on days 0, 2, 4, 6, 8 (heart allograft given day 0).

  • b Ten doses of 240 cGy given on days 1–3, 6–10, 13, and 14.

  • c A total of 50 × 106 cells injected i.v. on day 15.

  • d Day 28 after BM cell injection (= day 43 after heart transplantation). Adequate blood samples were not available for analysis in some hosts. NA, not applicable.