Table II.

Differential functional responses of MDC and PDC in HIV-infected individuals

PatientsMDCaPDCaInfluenza IFN-αbHSV-1 IFN-αbMLR SIcCD4 T Cells/mm3Viral Load (copies/ml)
P1830.310.1211798822050
P1870.30.1127815811.638850
P2690.550.2538849711.48950
P2710.30.1120213911.862250
P272ND0.193092019.618850
P2730.310.111618911.845950
P2750.290.1737521810.459850
P2770.210.298877.617573
P2700.140.121892099283112
P2780.440.1817822112.6340132
P1850.260.0990ND9.62892,480
P2760.410.19312234101,0507,150
P1840.090.2892202.531328,300
P1860.220.19289401760048,600
All patients (n = 14)0.29 ± 0.030.16 ± 0.013 217 ± 29221 ± 319.5 ± 0.7401 ± 676,228 ± 3,835
All controls (n = 8)0.30 ± 0.0350.32 ± 0.03 1,459 ± 370  1,113 ± 3069.22 ± 0.6
p valuesdNSp = 0.002p < 0.0003p < 0.0008NS
  • a Results represent percentage of positive cells ± SE. PDC are defined by HLA-DR+CD123+Lin.

  • b Viral stimulated IFN-α measured in picograms per milliliter ± SE.

  • c SI ± SE (SI as defined in Materials and Methods).

  • d Statistical significance between HIV and HIV+ was performed using the Wilcoxon tests.