Table I.

Ld-nOVA × DO11.10 mice have increased numbers of CD4+CD25+ regulatory T cells in the thymus and the periphery

 OrganCell SubsetDO11.10 (n = 7)Ld-nOVA × DO11.10 (n = 7)
ThymusTotal (× 108)1.8 ± 0.31.0 ± 0.2
CD4+ SP (× 107)a1.7 ± 0.8 (9.7)0.7 ± 0.3 (6.7)
CD4+CD25+ (× 105)b d2.0 ± 0.9 (1.2)2.7 ± 0.9 (4.0)
SpleenTotal (× 108)1.2 ± 0.31.0 ± 0.3
CD4+ (× 107)a2.9 ± 0.7 (24)1.3 ± 0.3 (13)
CD4+CD25+ (× 106)b **1.0 ± 0.3 (3.6)1.6 ± 0.3 (12.3)
Lymph nodescTotal (× 106)5.4 ± 0.94.3 ± 0.8
CD4+ (× 106)a3.3 ± 0.4 (62)1.5 ± 0.2 (35)
CD4+CD25+ (× 105)b ***1.1 ± 0.2 (3.3)2.7 ± 0.5 (18.2)
  • a The percentage of CD4+CD8 T cells in total thymocytes, splenocytes, or lymph node cells is shown.

  • b The percentage of CD4+CD25+ T cells in CD4+CD8 T cells is shown.

  • c Inguinal, axillary, and para-aorta lymph nodes were collected.

  • d , 0.2 > p ≥ 0.05; ∗∗, 0.05 > p ≥ 0.01; ∗∗∗, p < 0.01. Statistical comparison is by Student’s t test.