Table I.

Characteristics of the primary response

OrganDays After Infectiona% Virus-Specific CD8+ T CellsNo. of Virus-Specific CD8+ T Cellsb
p79p56p79p56
I-Ab+/+I-Ab−/−I-Ab+/+I-Ab−/−I-Ab+/+I-Ab−/−I-Ab+/+I-Ab−/−
Spleen100.2 ± 0.1c0.6 ± 0.20.8 ± 0.11.1 ± 0.20.2 ± −0.1c1.0 ± 0.21.0 ± 0.21.7 ± 1.0
202.7 ± 1.21.7 ± 1.20.7 ± 0.11.0 ± 0.32.9 ± 1.82.7 ± 0.90.8 ± 0.21.5 ± 0.9
402.3 ± 0.62.0 ± 0.20.7 ± 0.3c1.7 ± 0.73.4 ± 2.12.8 ± 0.51.4 ± 0.63.0 ± 2.1
PBL101.61.311.610.20.20.51.63.7
206.41.13.92.80.20.10.10.3
404.62.91.12.21.10.41.30.9
  • a The B6 I-Ab+/+ and I-Ab−/− mice were infected i.n. with 104 PFU of γHV68.

  • b The mean ± SD spleen cell counts (per mouse) are × 105, while the values for the pooled PBL samples are × 103 for Ficoll-separated lymphocytes from 1.0 to 1.5 ml of heparinized blood.

  • c Significantly different (p < 0.05).