Relationship between malaria infection status determined by PCR and T cell cytokine responses to MSP-119
| P. falciparum Status by PCRa | Fetal T Cell Response | Maternal T Cell Response | ||
|---|---|---|---|---|
| Yesb | No | Yesb | No | |
| Infected | 16 (70%)c | 7 (30%) | 23 (70%)d | 10 (30%) |
| Not infected | 6 (15%) | 35 (85%) | 9 (45%) | 20 (55%) |
a P. falciparum status was determined by PCR amplification of small subunit rDNA.
b T cell cytokine IFN-γ and IL-4 responses were determined by ELISPOT as described in Materials and Methods.
c This value is significantly greater than “not infected” newborns with χ2 = 19.7, p < 0.0001.
d This value is significantly greater than “not infected” women with χ2 = 9.2, p = 0.002.