Table IV.

Relationship between malaria infection status determined by PCR and T cell cytokine responses to MSP-119

P. falciparum Status by PCRaFetal T Cell ResponseMaternal T Cell Response
YesbNoYesbNo
Infected16 (70%)c7 (30%)23 (70%)d10 (30%)
Not infected6 (15%)35 (85%)9 (45%)20 (55%)
  • a P. falciparum status was determined by PCR amplification of small subunit rDNA.

  • b T cell cytokine IFN-γ and IL-4 responses were determined by ELISPOT as described in Materials and Methods.

  • c This value is significantly greater than “not infected” newborns with χ2 = 19.7, p < 0.0001.

  • d This value is significantly greater than “not infected” women with χ2 = 9.2, p = 0.002.