Table I.

Cord blood lymphocyte cytokine responses to MSP-119 and LSA-1 peptides

AgConstructNumber Positive Responses/Number EvaluatedaGeometric Mean Cytokine Productionb
IFN-γIL-4
MSP-119Q-KNGc17 /92 (18%)20 (4–168)17 (4–132)
MSP-119E-KNG10 /64 (16%)15 (4–218)13 (4–88)
MSP-119Q-TSR7 /56 (13%)14 (5–184)18 (4–69)
MSP-119E-TSR15 /91 (16%)16 (4–192)23 (5–64)
MSP-119Any variant24 /92 (26%)15 (4–218)17 (4–132)
LSA-184–107d0 /5500
LSA-11888–19090 /5300
  • a Positive responses are defined as values of >4 cytokine-secreting cells per 106 lymphocytes or at least 2-fold greater than parallel wells containing media alone.

  • b Geometric mean number of cytokine-secreting cells per 106 lymphocytes were determined by ELISPOT as described in Materials and Methods.

  • c MSP-119 variants correspond to amino acid changes encoded by codons 1644, 1691, 1700, and 1701, respectively.

  • d LSA-1 peptides are based on GenBank number X56203.