Table II.

Clinical data on vaccinated rhesus monkeys infected with SHIV-89.6Pa

Rhesus MonkeyInfecting VirusViral Load (RNA copies/ml)CD4 Count (count/μl)
IL-2-Ig protein+ DNA vaccines
798SHIV-89.6P1323888
772SHIV-89.6P1166667
839SHIV-89.6P<500720
712SHIV-89.6P<5001085
IL-2-Ig plasmid+ DNA vaccines
893SHIV-89.6P6511276
833SHIV-89.6P<500858
483SHIV-89.6P<5001554
728SHIV-89.6P719968
  • a Clinical status of the vaccinated group of rhesus monkeys on day 150 postchallenge. Animals were immunized with an HIV-gp120-encoding plasmid and an SIVmac Gag encoding plasmid with IL-2/Ig delivered either as a protein or plasmid, prior to challenge with the pathogenic SHIV-89.6P isolate.