Table I.

Frequency of naive T cells in peripheral blood vs lymphoid tissues

AnimalAge (years)% Naive (blood:tissue ratio)a
CD4CD8
BloodPLNbMLNSpleenBloodPLNMLNSpleen
1669310.866.266.7 (0.99)60.1 (1.10)44.5 (1.49)64.082.7 (0.77)70.8 (0.90)41.5 (1.54)
178927.156.749.0 (1.16)71.8 (0.79)16.9 (3.36)53.862.7 (0.86)72.3 (0.74)12.0 (4.48)
2014013.935.032.1 (1.09)38.5 (0.91)18.8 (1.86)51.553.7 (0.96)56.1 (0.92)20.2 (2.55)
1500713.940.335.2 (1.15)55.9 (0.72)13.0 (3.10)47.446.1 (1.03)61.9 (0.77)16.1 (2.94)
181977.055.066.1 (0.83)69.8 (0.79)20.7 (2.66)25.660.8 (0.42)67.2 (0.38)5.4 (4.74)
1629710.950.653.4 (0.95)55.6 (0.91)29.9 (1.69)42.472.4 (0.59)66.3 (0.64)22.1 (1.92)
158439.331.242.5 (0.73)44.5 (0.70)12.7 (2.46)59.469.6 (0.85)77.3 (0.77)13.3 (4.47)
18468c6.175.678.4 (0.96)80.7 (0.94)23.7 (3.19)56.673.6 (0.77)72.5 (0.78)27.3 (2.07)
Mean ratio0.980.862.480.780.743.09
  • a Naive subset defined by CD95, CD28, and either β7 integrin (CD4+ T cells) or CD11a (CD8+ T cells) expression as described in Fig. 1 legend.

  • b Inguinal and axillary.

  • c Attenuated SIV infected.