Table I.

Full haplotypes of 42 SCIDA chromosomes in the SCIDA regiona

No. of ChromosomesMarkers in SCIDA Candidate RegionMutation(s)
D10S1664D10S19185F9F1R122A2F1R11000B2F1R12K17F2R2SCIDA geneP853B18atFR2O14-1FR2O14-2FRD10S165374L17F2R2D10S674
Navajo
14 4 8 7 2 2 2 2 1b 1b 2/4b5/6b 4 C576A/Y192Xc
12 4 8 7 2 2 2 1 3b 2b 2/45/6 4 C576A/Y192X
2 4 8 7 2 2 2 2 1 1 2/45/61C576A/Y192X
1 4 8 7 2 2 2 1 3 2 2/45/61C576A/Y192X
21 8 7 2 2 2 1 3 2 2/45/65C576A/Y192X
16 8 7 2 2 2 2 1 1 2/45/65C576A/Y192X
14 8 7 2 2 2 2 1 1 678C576A/Y192X
27983 2 2 2 1 1 2 6 4 C576A/Y192X
1d10653 2 2 2 1 1 2 49Unknown
Apache
2 4 8 7 2 2 2 1 3 2 4 5 4 C576A/Y192X
2 4 8 7 2 2 2 2 1 1 2 6 4 C576A/Y192X
1 4 8 7 2 2 2 2 1 1 2 6 4 C576A/Y192X
16213 2 2 2 1 1 2 6 4 C576A/Y192X
  • a The alleles at each locus are represented by numbers (in order) starting from 1 for the smallest allele seen in normal controls. SCIDA-associated alleles at each marker locus are boldface and the SCIDA locus is blank.

  • b Both alleles associated with SCIDA and rare in normal controls.

  • c The nonsense founder mutation.

  • d The haplotype from the 30-A1 maternal allele.