Table I.

Clinical severity of EAEa

MicenDay of Onset (SEM)Mean Maximum Severity (SEM)Mean Cumulative Severity (SEM)Relapses (SEM)Mortality (%)
NOD2310.9 (±0.6)2.7 (±0.2)83.1 (±9.2)0.7 (±0.2)1 /23 (4.3)
NOD Vα14-Jα2812221.9 (±3.3)b1.4 (±0.3)c26.1 (±6.7)d0.2 (±0.2)1 /22 (4.5)
NOD712.9 (±1.0)2.6 (±0.5)81.1 (±26.0)0.6 (±0.2)1 /7 (14.3)
NOD CD1d−/−711.2 (±0.9)2.9 (±0.7)89.1 (±23.3)0.4 (±0.3)2 /7 (28.5)
  • a Shown are the pooled data from three independent experiments comparing Vα14-Jα281 Tg vs non-Tg NOD and one experiment involving the CD1d−/− and CD1d+/+ NOD mice.

  • b Value of p < 0.0003 (log rank test).

  • c Value of p < 0.001 (RIDIT analysis).

  • d Value of p < 0.0001 (Mann-Whitney U test).