Table I.

Vβ-specific CD69 up-regulation on CD4 T cells in response to incubation with CVB4 Ags^a

Subject	HLA-DR Genotype	Vβ Chain
Subject	HLA-DR Genotype	1	2	3	5	6	7	8	11	12	13	14	16	17	20	21	22
C1	03,15			X^b	X	X	X	X	X		X	X		X	X
C2	04,15			X			X		X	X	X	X				X	X
C3	03,15							X			X						X
C4	04,15		X		X			X	ND	X			ND	X		X
C5	03,07	X					X	X	X	X	X		X	X	X
C6	01,13					X	X		X	X	X		X		X
C7	04,04	X	X		X	X			X				X	X
C8	03,03	X	X		X					ND					X	X	X
% positive		37.5	37.5	25	50	37.5	50	50	71.4	57.1	62.5	25	42.9	50	50	37.5	37.5
D1	03,04		X	X	X	X		X	X		X				X		X
D2	01,01			X	X		X	X		X			X		X
D3	01,08		X				X	X	ND	X			ND	X	X	X
D4	03,04	X	X			X	X	X		X				X	X		X
D5	03,03		X					X	X			X	X	X		X	X
D6	03,04	X		X	X	X	X	X	ND	X						X
D7	04,07		X	X	X	X	X	X	X	X	X		X	X		X
D8	03,13	X	X	X			X	X	X			X	X			X	X
% positive		37.5	75	62.5	50	50	75	100*	66.7	62.5	25	25	57.1	50	50	62.5	50
Total positive (%)		37.5	56.3	43.8	50	43.8	62.5	75	69.2	60	43.8	25	50	50	50	50	43.8

a C1–8, Control subjects; D1–8, patients with type 1 DM.
b X, positive response to CVB4; ND, not done.
c , p < 0.05 compared with healthy controls.