Table I.

Lymphoid organ weights and cellular subsets of BXSB TCRα−/− micea

TCRαSpleen WeightLN WeightCD4+ SubsetCD8+ SubsetCD19+PBMC Mac-1+
TotalCD44highTotalCD44high
−/−0.2 ± 0.5b0.04 ± 0.01b1.2 ± 0.050.8 ± 0.0185.5 ± 0.9b8.9 ± 0.1b
+/+0.4 ± 0.050.4 ± 0.0217.7 ± 1.584.9 ± 2.72.3 ± 0.381.2 ± 2.774.9 ± 1.421.2 ± 3.2
  • a CD4+, CD8+, and CD19+ are expressed as percentage of total splenocytes, CD44high as percentage of splenic CD4+ or CD8+ cells, and Mac-1+ as percentage of PBMC. LN (axillary, inguinal, cervical, and mesenteric) and spleen weights are in grams. Values are means ± SEM of six to eight mice per group at 5 mo.

  • b , p < 0.05 between knockout and WT mice.