Table II.

B cell maturation in E2-treated BALB/c mice

B220+ B Cell PopulationPE2p Valuea
Bone marrow-totalb26.7 (±2.8)19.4 (±4.7)<0.03
Splenic-totalb44.1 (±4.7)43.8 (±4.7)NS
Splenic-transitionalc
Type 121.1 (±2.3)5.4 (±2.5)<0.000001
Type 210.5 (±2.2)6.7 (±3.7)<0.03
Splenic-maturec
Follicular62.7 (±7.2)68.7 (±6.4)NSd
Marginal zone5.8 (±1.3)19.9 (±2.5)<0.000001
  • a An unpaired Student’s t test was performed to determine statistical significance of P (n = 5)- and E2 (n = 7)-treated BALB/c mice.

  • b Data are presented as a percentage of lymphoid gated cells.

  • c B220+ subsets were distinguished by CD21 and HSA staining.

  • d NS, Not statistically significant.