Table IV.

Protection from diabetes in NOD.Ins-IL-10 mice correlates with the expression of BALB/c-derived MHC I Dd

No. of MiceH-2D HaplotypeIncidence of IDDM at 8 wk of Agea% Protection
DbDd
30+28 /306.7
14+0 /14100
10++0 /10100
  • a Blood glucose level was measured at weekly intervals starting at 4 wk of age from N7 to N11 backcross generations of NOD.Ins-IL-10 mice. Mice with a blood glucose level ≥300 mg/dl were considered diabetic.