Table I.

Total collagen levels in whole lunga

NRSAnti-IL-13 (μg/ml/lung)Anti-IL-4
Days 0–1474.4 ± 4.863.4 ± 3.473.0 ± 7.8
Days 14–3088.2 ± 7.760.9 ± 1.6b62.8 ± 8.2
Days 30–3875.2 ± 5.987.7 ± 2.284.2 ± 5.4
  • a Total collagen levels in whole lung (μg/ml/lung) at day 38 after live A. fumigatus conidia challenge were assessed following neutralization of IL-4 or IL-13 between days 0 and 14, days 14 and 30, or days 30 and 38. Values are expressed as mean ± SEM; n = 4–5/group/time point.

  • b , p < 0.05 denotes significant inhibition of collagen levels compared to NRS-treated controls.