Table I.

Rejection of different H-2Kb+ allografts by defined numbers of H2Hb-specific T cellsa

No. of tg-TCR+ CD8+Individual Graft Survival Time
HeartSkinIslet
No cells8× >508× >5010× >50
6× 1063× 15, 18, 21, 2× >504× 20, 3 × 231, 3× 2
4× 1068× >5022, 2× 262× 5
2× 1062× 26, 305, 11
1 × 10616, 28, 312× 12
1× 10522, 2× 272× 4, 26
1× 10437, >502× 12, >50
1× 10332, 35, >504, 12, >50
5003× >503× >50
1003× >50
  • a Athymic, T-depleted CBA (H-2k) recipients were reconstituted with graded numbers of purified H-2Kb-specific CD8+ T cells the day before transplantation of a H-2Kb+ heart, skin, or islet allograft. Grafts were deemed to be rejected according to the criteria defined in Materials and Methods.