Table I.

Effect of IKK1 wt on IL-6 and IL-8 productiona

ConstructMediumTNF-α
IL-6 (pg/ml)IL-8 (pg/ml)IL-6 (pg/ml)IL-8 (pg/ml)
None481 ± 241,037 ± 6210,611 ± 1,04637,542 ± 6,529
GFP506 ± 18990 ± 2812,489 ± 1,20529,610 ± 4,639
IKK1 wt757 ± 521,108 ± 8115,386 ± 31531,778 ± 6,414
IKK2 wt5,039 ± 30811,164 ± 16713,878 ± 91442,148 ± 1,191
  • a FLS were infected with various adenoviral constructs and then stimulated with either medium or TNF-α for 18 h. Supernatants were collected and assayed for IL-6 and IL-8 by ELISA. Each condition was performed in triplicate.