Table II.

Serum biochemistry markers summarizing significant changes to bone enzyme markersa

ALP (IU/I)ACP (IU/I)TRAP (IU/I)
RU24858 (mg/kg/day)
0424 ± 727.7 ± 1.4310.6 ± 0.95
0.3386 ± 22 (−9%)27.3 ± 1.57 (−2%)10.3 ± 0.87 (−3%)
1.0420 ± 14 (−1%)23.7 ± 2.07 (−14%)8.7 ± 1.13 (−18%)
3.0341 ± 10 (−19%)19.9 ± 1.41** (−28%)6.9 ± 0.91* (−35%)
10308 ± 22** (−27%)9 ± 1.01** (−67%)1.9 ± 0.55** (−82%)
30345 ± 41 (−19%)12.8 ± 1.00** (−54%)4.0 ± 0.71** (−62%)
100209 ± 15** (−51%)10.1 ± 0.77** (−63%)3.6 ± 0.46** (−66%)
prednisolone (mg/kg/day)
0494 ± 1922.1 ± 0.89.4 ± 0.48
1.0469 ± 14 (−5%)19 ± 1.5 (−14%)7.6 ± 0.72 (−20%)
3.0479 ± 44 (−3%)18.7 ± 1.2 (−15%)7.9 ± 0.59 (−17%)
10493 ± 22 (0%)18.8 ± 1.0 (−15%)8.2 ± 0.60 (−13%)
30448 ± 17 (−10%)16 ± 0.7** (−28%)6.9 ± 0.40** (−27%)
100262 ± 19** (−47%)12 ± 1.3** (−46%)4.7 ± 0.76** (−51%)
budesonide (mg/kg/day)
0557 ± 1922.7 ± 1.39.6 ± 0.7
0.3534 ± 23 (−4%)25.6 ± 2.0 (13%)11.3 ± 0.9 (18%)
1.0514 ± 34 (−8%)21.0 ± 1.1 (−8%)8.0 ± 0.5 (−16%)
3.0414 ± 6.2** (−26%)19.9 ± 1.7 (−13%)7.4 ± 0.9 (−22%)
10384 ± 35** (−31%)14.3 ± 1.5** (−37%)6.0 ± 0.9** (−37%)
30278 ± 25** (−50%)12.4 ± 0.8** (−45%)4.7 ± 0.9** (−51%)
  • a , Values are shown ± SEM. *, p < 0.05, ∗∗, p < 0.01 relative to control (ANOVA, Dunnett’s test).