Table I.

Comparison of typhlocolitis in H. hepaticus-infected NF-κB-deficient and WT micea

WT (n = 15)p50+/+p65+/− (n = 10)p50−/−p65+/+ (n = 15)p50−/−p65+/− (n = 19)
Cecum1 (0–2)b1 (1–2)3 (2–4)4 (3–4)
p = 0.3490p < 0.00001cp < 0.00001c
p = 0.0007d
Colon1 (0–2)1 (1–2)3 (2–3)4 (3–4)
p = 0.1481p = 0.0001cp < 0.00001c
p < 0.00001d
  • a Inflammation and hyperplasia of cecum and colon were evaluated histologically and scored 0–4 as described in the text. Data were subjected to the Mann-Whitney U test by comparison of each NF-κB mutant and WT or p50−/−. Data are presented as median score and range. Typhlitis (p50−/− and p50−/−p65+/−) and colitis (p50−/− and p50−/−p65+/−) were significantly elevated compared to infected WT mice, and typhlitis (p50−/−p65+/−) and colitis (p50−/−p65+/−) were significantly elevated compared to infected p50−/− mice.

  • b Median score (range).

  • c Mann-Whitney U test, comparison to H. hepaticus-infected WT value.

  • d Mann-Whitney U test, comparison to H. hepaticus-infected p50−/− value.