Table I.

Correlation of high BLyS levels with anti-dsDNA Aba

NormalSLE
BLyShighBLySlow
Number101010
BLyS4.87 ± 0.9920.77 ± 2.37***4.61 ± 0.51
Anti-dsDNA-IgG0.108 ± 0.0171.615 ± 0.427***0.242 ± 0.080
(0/10)(8/10)(3/10)
Anti-dsDNA-IgM0.058 ± 0.0080.712 ± 0.292***0.104 ± 0.016
(0/10)(8/10)(2/10)
Anti-dsDNA-IgA0.055 ± 0.0050.170 ± 0.038***0.060 ± 0.009
(0/10)(6/10)(1/10)
Total IgG (μg/ml)1898 ± 1882560 ± 221*1729 ± 183
Total IgM (μg/ml)182 ± 21193 ± 30206 ± 20
Total IgA (μg/ml)437 ± 85693 ± 138**610 ± 47
  • a SLE samples were divided into BLyShigh and BLySlow groups and compared to normal controls. Anti-dsDNA Ab and total IgG, IgM, and IgA were determined by ELISA. The results are presented as mean ± SEM. The positive value was determined by the mean + 3 SD of normal control. The p value was determined by t test and ANOVA test between the BLyShigh and BLySlow groups.

  • b ∗∗, p < 0.0001; ∗∗, p < 0.005, ∗, p < 0.05.