Table I.

IL-18 −/− have reduced levels of proinflammatory cytokines in seruma

Cytokine (pg/ml)Wild TypeIL-18−/−p
IFN-γ336.7 ± 64.6121.1 ± 18.4<0.01
TNF-α605.3 ± 173.1200.1 ± 29.0<0.01
IL-6427.1 ± 53.4193.5 ± 51.4<0.01
IL-1029.6 ± 5.127.7 ± 8.3NS
  • a Serum cytokine concentrations in wild type and IL-18−/−. Sera were obtained from mice on day 37 and cytokine levels were measured by ELISA. Results are the means ± SD (six mice per group). p < 0.01 (wild-type vs IL-18−/−, Student’s t test).