Table I.

Effect of administration of single neutralizing Abs against specific C-C chemokines on leukocyte recruitment in BAL fluid of mice 2 days after infection with S. pneumoniaea

Treatment of MiceNo. of MiceNo. of Monocytes/Macrophages (104)
Control IgG+ S. pneumoniae54.3 ± 0.3
Anti-MCP-1+ S. pneumoniae65.7 ± 1.2
Control IgG+ S. pneumoniae67.6 ± 2.6
Anti-MIP-1α+ S. pneumoniae66.3 ± 1.1
Control IgG+ S. pneumoniae64.0 ± 0.7
Anti-RANTES+ S. pneumoniae55.9 ± 0.8
  • a Results are expressed as means ± SEM. Mice were administered three doses of anti-MCP-1, anti-MIP-1α, or anti-RANTES at 30 min before infection, 24 h and 48 h after infection. The time of sacrifice was 6 h after the final treatment (54 h postinfection).