Table I.

Costimulatory effects of TGF-β on alloactivated naive T cellsa

Control (%)TGF-β (%)p
CD2534.5 ± 3.842.3 ± 3.6<0.01
CTLA-4
Intracellular23.2 ± 4.531.5 ± 4.1<0.01
Surface5.2 ± 0.410.8 ± 0.9<0.01
  • a CD45RO-depleted CD4+ cells were stimulated with irradiated allogeneic non-T cells for 5 days with or without TGF-β and stained for the markers indicated as described in Materials and Methods. p values were determined using the paired t test. N = 13.