Table II.

Frequency of insulitis in nondiabetic NOD mice receiving GAD65-specific Th clones at 12 wk of agea

Th Cell CloneNo InfiltrationPeri-insulitisIntrainsulitis
IF2 (n=1)7/49 (14.3%)8/49 (16.3%)34/49 (69.4%)
6H1E (n=9)90/320 (28.1%)b96/320 (30.0%)134/320 (41.9%)b
6H1L (n=2)15/156 (9.6%)28/156 (17.9%)113/156 (72.5%)
Untreated (n=3)8/192 (4.2%)29/192 (15.1%)155/192 (80.7%)
  • a Insulitis was determined by counting islets in nondiabetic mice 35 wk of age.

  • b Values of p < 10−3 vs untreated mice as determined by χ2 analysis.